There's a fight in Act II where you have to save someone and, as far as I can tell, it is just completely impossible.
To add insult to injury, there's a loooooong cut scene that plays between when you can save before the fight and the actual fight.
I might have to go respec all of my characters (or, certainly, my main since I can't swap her out of the party) to build a party just for this fight.
I shouldn't have spent all my gold on shiny swords, I guess.
Maybe I need a Paladin in this fight. Hmmm...
Better go talk to Withers.