Despite being the 75th largest metro area in the U.S., Charleston is ranked in the top 10 fastest growing cities for software and Internet technology, according to the Charleston Regional Development Alliance.
TwitPic and Amazon's CreateSpace count among the household names to emerge from Charleston. Additional prominent companies with footprints in the city include Blackbaud, Boeing, and Google.
As Charleston becomes increasingly high-tech, it'll be interesting to see if the old and stuffy society here manages to survive.
Additionally, I'm not sure that Google should count since their data-center is pretty insular and doesn't really drive innovation (all of that happens elsewhere and is then shipped here to be installed by technicians). But we have BenefitFocus and PeopleMatter too. And then the article mentions BiblioLabs which I'd never heard of but sounds really cool. I hope to meet someone from there one day.
Maybe it's time to bring back and/or start going to the tweetups again.